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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

MAL

contributors: mct - updated : 08-06-2017

HGNC name	mal, T-cell differentiation protein
HGNC id	6817

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in esophageal cancer tumoral     --low   in head and neck squamous cell carcinoma tumoral     --low   most down-regulated gene in cervical cancer, by promoter methylation (by promoter methylation) constitutional     --over   is also associated with shortened or absent cilia, and cyst development constitutional     --over   leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells

Susceptibility

Variant & Polymorphism SNP

Candidate gene
Marker	inactivation of MAL, as a candidate tumor suppressor gene, can contribute to human epithelial cell carcinoma and may be served as a biomarker in head and neck squamous cell carcinoma
Therapy target

ANIMAL & CELL MODELS

overexpression of MAL/VIP17 in the kidney of transgenic mice results in cysts formation in distal nephron structures