SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| basic FUNCTION
| involved in formation, stabilization and maintenance of glycosphingolipid and cholesterol-enriched membrane microdomains (raft5) |
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could be an important component in vesicular trafficking cycling between the golgi complex and the apical plasma membrane |
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could be involved in myelin biogenesis and/or myelin function |
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required in T cells for efficient expression of LCK at the plasma membrane and activation of IL2 transcription  |
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required for recruitment of LCK to specialized membranes and formation of specific transport carriers for LCK targeting |
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potentially having a functional role in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping |
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may be playing an important role in apical sorting or in maintaining the stability of the apical membrane |
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involvement of MAL in the activation and surface expression of SLC12A1 could play an important role in the regulated absorption of Na+ and Cl- in the kidney |
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MAL, but not MAL2, self-associates, forms higher-order cholesterol-dependent complexes with apical proteins and promotes the formation of detergent-resistant membranes that recruit apical prote |
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role for MAL in raft coalescence and stabilization |
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is involved in apical vesicle transport |
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in epithelial cells, the MAL family members MAL, MAL2, and MYADM regulate the function and dynamics of ordered membrane domains |
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is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains |
