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FLASH GENE
Symbol CPT2 contributors: npt/ - updated : 23-03-2007
HGNC name carnitine palmitoyltransferase II
HGNC id 2330
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal leader peptide 25 AA
  • carnitine O-acetyltransferase domain
    • HOMOLOGY
    interspecies ortholog to murine Cpt2
    Homologene
    FAMILY
  • carnitine/choline acetyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • carnitine palmitoyltransferase, malonyl CoA insensitive involved in transesterification of lung and medium fatty acyl chains
  • converting palmitoylcarnitine into palmitoyl-CoA (palmitoyl-CoA shuttle system)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    fatty acid beta oxidation pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by not inhibited by malonyl-CoA
    ASSOCIATED DISORDERS
    corresponding disease(s) CPT2 , CPT2I
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS