basic FUNCTION
| enhance ARF-dependent and -independent wild-type TP53 function |
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playing a role in senescence of primary cells and activating pathways for cell cycle control and tumor suppression |
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plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms |
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required for normal progression and completion of cell division and its absence causes mitotic catastrophe/apoptosisb |
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pleiotropic regulator with widespread effects |
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has a vital role in genome preservation and tumor suppression |