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FLASH GENE

Symbol

LIF

contributors: mct/npt - updated : 05-11-2020

HGNC name	leukemia inhibitory factor (cholinergic differentiation factor)
HGNC id	6596

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   higher levels of CD34, CD44, and LIF were found in the placentas of pre-eclamptic compared with normotensive women

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	may be useful, in combination with other factors, in promoting regeneration in the adult brain
	targeting IL11 and LIF may be useful in regulating fertility by either enhancing or blocking implantation (Marwood 2009)
	potentially effective drug target in the treatment of bone metastasis in melanoma (Maruta 2009)

ANIMAL & CELL MODELS