| basic FUNCTION
| cholinergic neuronal differentiation factor |
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inducing macrophage differentiation and in conjunction with BMP2 acting in synergy on primary fetal neural progenitor cells to induce astrocytes |
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inducing multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16 |
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plays a central role in the control of uterine implantation |
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reduces neurogenesis in the olfactory bulb and subventricular zone by acting directly on neural stem cells and promote neural stem cells self-renewal, preventing the emergence of more differentiated cell types |
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involved in the control of osteoclast survival and size |
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with IL11 regulated endometrial epithelial cell adhesion (Marwood 2009) |
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potential role for LIF in the melanoma-induced bone metastasis possibly through the stimulation of osteoclastogenesis (Maruta 2009) |
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inhibits osteoblast development at least in part by stimulating high molecular weight HA synthesis through HAS2 (Falconi 2007) |
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playing a role in mesenchymal stem cells mediated immunosuppression (Nasef 2008) |
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might be one of the reasons that cause patients with salpingitis to be more susceptible to tubal pregnancy and might be involved in the implantation process of tubal pregnancy (JI 2009) |
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with CNTF, LEP, IL6, participate to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites (Dozio 2009) |
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LIF stimulates muscle satellite cell proliferation and is involved in muscle hypertrophy and regeneration  |
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fundamental role of LIF for pluripotency was highlighted further by the discovery that LIF accelerates the conversion of epiblast-derived stem cells into a more fully pluripotent state |
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LIF is protective of the myocardium in the acute stress of ischemia-reperfusion |
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LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development |
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roles of LIF in central nervous system development |
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important roles for LIF signaling during development and homeostasis |
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role for LIF in the generation and particularly maturation of Dendritic cells (DCs) |
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assumes a crucial role in the regulation of CD8+ T cell tumor infiltration, while promoting the presence of protumoral tumor-associated macrophages |
