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FLASH GENE
Symbol DOLK contributors: mct/npt - updated : 08-10-2013
HGNC name dolichol kinase
HGNC id 23406
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus extended into the lumen and a cytoplasmically oriented C terminus
  • cytoplasmic loop between TMDs 11-12, containing the critical conserved residues, lysine 470 and lysine 471 in the (470)KKTXEG(475) motif, is part of the CTP-binding site
    • HOMOLOGY
    interspecies homolog to rattus Tmem15 (95.3 pc)
    homolog to murine Tmem15 (95.3 pc)
    homolog to chicken TMEM15 (78.5 pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text
  • integral membrane protein
    • basic FUNCTION
  • may have a dolichol kinase activity
  • catalyzes the CTP-dependent phosphorylation of dolichol in the biosynthesis de novo and possibly the recycling of dolichyl monophosphate
  • acting as a phosphatidase cytidylyltransferase
  • responsible for the final step of the biosynthesis of dolichol phosphate, involved in several glycosylation reactions, such as N-glycosylation, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, and C- and O-mannosylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • phospholipid biosynthesis
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DK1D , CDG1M
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS