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FLASH GENE
Symbol LCT contributors: - updated : 09-10-2006
HGNC name lactase
HGNC id 6530
Corresponding disease
LCT congenital lactase deficiency
Location 2q21      Physical location : 136.545.414 - 136.594.750
Synonym name lactase/phlorizin hydrolase
Synonym symbol(s) LPH, LAC
EC.number 3.2.1.62, 3.2.1.108
DNA
TYPE functioning gene
STRUCTURE 49.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map see IL1RN
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrinethyroid    
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY glycosylhydrolase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • beta-galactosidase from intestinal mucosa
  • putatively involved in downregulation and DNA binding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LCT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS