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FLASH GENE
Symbol CATSPER4 contributors: npt/ - updated : 21-09-2007
HGNC name cation channel, sperm associated 4
HGNC id 23220
Location 1p36.11      Physical location : 26.517.118 - 26.529.032
Synonym name putative ion channel CatSper4
Synonym symbol(s) MGC149223
DNA
TYPE functioning gene
STRUCTURE 11.91 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1419 - 472 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatozoa
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil protein-protein interaction domain in the C-terminal tail
  • a single-ion transport domain with six transmembrane spanning regions, in which the fourth transmembrane region resembles a voltage sensor and a pore-forming region lies between transmembrane regions 5 and 6
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to CATSPER1, CATSPER2
    Homologene
    FAMILY
  • Catsper family
  • cation channel sperm-associated family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • forms a hetero-tetrameric channel in sperm (in association with Catsper 1, 2, 3)
  • cation-channel protein having roles in acrosome reaction and male fertility
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS