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FLASH GENE
Symbol CATSPER4 contributors: npt/ - updated : 21-09-2007
HGNC name cation channel, sperm associated 4
HGNC id 23220
Location 1p36.11      Physical location : 26.517.118 - 26.529.032
Synonym name putative ion channel CatSper4
Synonym symbol(s) MGC149223
DNA
TYPE functioning gene
STRUCTURE 11.91 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC388608 1 similar to mutant membrane protein RhCe FLJ10747 1p36.11 hypothetical protein FLJ10747 ARH MAN1C1 1p35 mannosidase, alpha, class 1C, member 1 SEPN1 1p36.13 selenoprotein N, 1 LOC56181 1p35.3 hypothetical protein RP1-317E23 MGC2603 1p35.3 hypothetical protein MGC2603 MPRA 1p36.11 hypothetical protein MGC2603 FLJ32206 1p35.3 hypothetical protein FLJ32206 STMN1 1p36.11 stathmin 1/oncoprotein 18 LOC388609 1 LOC388609 PAFAH2 1p34.2 platelet-activating factor acetylhydrolase 2, 40kDa EXTL1 1p36.1 exostoses (multiple)-like 1 SLC30A2 1p35.3 solute carrier family 30 (zinc transporter), member 2 RNF28 1p34-p33 ring finger protein 28 LOC149420 1p35.3 casein kinase FLJ14050 1p35.3 hypothetical protein FLJ14050 ZT86 1p35.3 zinc finger protein CNK1 1p35.3 zinc finger protein CATSPER4 1p35.3 cation channel, sperm associated 4 LOC391021 1 similar to secreted acid phosphatase 2 (SAP2) DKFZP434L0117 1p35.3 hypothetical protein DKFZp434L0117 MRPS6P1 1p35 mitochondrial ribosomal protein S6 pseudogene 1 SH3BGRL3 1p35-p34.3 SH3 domain binding glutamic acid-rich protein like 3 SOC 1p35.3 SH3 domain binding glutamic acid-rich protein like 3 CDW52 1p36 CDW52 antigen (CAMPATH-1 antigen) AIM1L 1p35.3 absent in melanoma 1-like MGC33414 1p35.3 hypothetical protein MGC33414 LIN28 1p35.3 lin-28 homolog (C. elegans) DHDDS 1p35.3 dehydrodolichyl diphosphate synthase HMGN2 1p36.1 high-mobility group nucleosomal binding domain 2 RPS6KA1 1p36-p35 ribosomal protein S6 kinase, 90kDa, polypeptide 1 SMARCF1 1p36.1-p35 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 FLJ20477 1p35.3 hypothetical protein FLJ20477 ZDHHC18 1p35.3 zinc finger, DHHC domain containing 18 SFN 1p35.3 stratifin FLJ10349 1p35.3 hypothetical protein FLJ10349 FLJ12455 1p35.3-p35.1 hypothetical protein FLJ12455 NR0B2 1p36.1 nuclear receptor subfamily 0, group B, member 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1419 - 472 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
Reproductivespermatozoa
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • coiled-coil protein-protein interaction domain in the C-terminal tail
  • a single-ion transport domain with six transmembrane spanning regions, in which the fourth transmembrane region resembles a voltage sensor and a pore-forming region lies between transmembrane regions 5 and 6
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to CATSPER1, CATSPER2
    Homologene
    FAMILY
  • Catsper family
  • cation channel sperm-associated family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • forms a hetero-tetrameric channel in sperm (in association with Catsper 1, 2, 3)
  • cation-channel protein having roles in acrosome reaction and male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS