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FLASH GENE
Symbol ZNF469 contributors: shn/npt - updated : 09-11-2018
HGNC name zinc finger protein 469
HGNC id 23216
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid    
Lymphoid/Immunelymph node    
Nervousbrain    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five zinc finger domains
    • HOMOLOGY
    interspecies ortholog to ZNF469, Pan troglodytes
    ortholog to Znf469_predicted, Rattus norvegicus
    Homologene
    FAMILY
  • Krueppel C2H2-type zinc finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in transcriptional regulation
  • could act as a transcription factor involved in the synthesis and/or organization of collagen fibers (Abu et al, 2008)
  • ZNF469 is a nuclear transcription factor that regulates the synthesis and structure of collagen fibers in the cornea
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BCS
    Susceptibility to central corneal thickness variation and to glaucoma
    Variant & Polymorphism other
  • common variants contribute to central corneal thickness variation and to glaucoma in the general population (Lu 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS