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FLASH GENE
Symbol MYH14 contributors: mct - updated : 31-05-2016
HGNC name myosin, heavy polypeptide 14
HGNC id 23212
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal myosin domain
  • a myosin-like globular head domain
  • two Iq domains
  • positively charged region of the non-helical tailpiece promotes filament assembly
  • a C terminal myosin tail
    • mono polymer homomer , dimer , hexamer
    HOMOLOGY
    intraspecies homolog to MYH10, MYH9, MYH11
    Homologene
    FAMILY non muscle myosin heavy chain family (myosin II family)
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • cellular myosin playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
  • with MYH9, modulates neuronal cell adhesion (
  • with MYH10 was found to be critical for driving neuronal process outgrowth
  • nonsarcomeric conventional myosin motor, that must participate in distinctive cellular roles and reinforces our view that closely related motor isoforms drive diverse functions within neuronal cells
  • directly regulates cellular patterning and alignment within the cochlear sensory epithelium
  • MYH9, MYH10, MYH14 are involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics
  • MYH9, MYH10, MYH14 are a group of molecular motors involved in a wide variety of cellular processes including cytokinesis, migration, and control of cell morphology
  • although MYH9 and MYH10 form filaments with similar properties, MYH14 forms filaments that are less well suited to roles such as tension maintenance within the cell
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    ATP binding
    protein
  • interacting with cytoskeletal actin in absence of ATP
  • SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, CEP131), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome
  • LIMCH1 plays a positive role in regulation of MYH14 activity through effects on myosin regulatory light chain (MRLC) during cell migration
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA4 , PNMHH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS