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FLASH GENE

Symbol

MYH14

contributors: mct - updated : 31-05-2016

HGNC name	myosin, heavy polypeptide 14
HGNC id	23212

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DFNA4 neurosensory deafness 4 PNMHH peripheral neuropathy, myopathy, hoarseness, and hearing loss
Location	19q13.33      Physical location : 50.706.884 - 50.813.801
Synonym name	nonmuscle myosin heavy chain II-C
	myosin 2C
Synonym symbol(s)	FLJ13881, KIAA2034, NHMCII, NMHC-II-C, FP17425, DFNA4, DKFZp667A1311, FLJ43092, MHC16
EC.number	3.6.4.1

DNA

TYPE	functioning gene
STRUCTURE	106.92 kb     43 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	two splice variants

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001145809 43 - 6930 - 2036 - 2009 19240025 NM_001077186 42 - 6831 - 2003 - 2009 19240025 NM_024729 41 - 6807 - 1995 - 2009 19240025 MYH14, variant 4 - - 650 - - expressed only in neuronal tissue 2009 19240025 NM II-C2, that is generated by alternative splicing of an exon, C2, encoding 33 AAs

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   mouth tongue     highly Hearing/Equilibrium ear inner cochlea Corti   Homo sapiens Nervous brain           nerve spinal nerve sciatic     Respiratory respiratory tract larynx     highly Skin/Tegument skin appendages hair follicle     Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Hearing / Equilibrium cochlea cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	embryonic cartilage

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal myosin domain
	a myosin-like globular head domain
	two Iq domains
	positively charged region of the non-helical tailpiece promotes filament assembly
	a C terminal myosin tail

mono polymer

homomer , dimer , hexamer

HOMOLOGY

intraspecies

homolog to MYH10, MYH9, MYH11

Homologene

FAMILY

non muscle myosin heavy chain family (myosin II family)

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	cellular myosin playing a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
	with MYH9, modulates neuronal cell adhesion (
	with MYH10 was found to be critical for driving neuronal process outgrowth
	nonsarcomeric conventional myosin motor, that must participate in distinctive cellular roles and reinforces our view that closely related motor isoforms drive diverse functions within neuronal cells
	directly regulates cellular patterning and alignment within the cochlear sensory epithelium
	MYH9, MYH10, MYH14 are involved in regulating cardiac myocyte karyokinesis by affecting microtubule dynamics
	MYH9, MYH10, MYH14 are a group of molecular motors involved in a wide variety of cellular processes including cytokinesis, migration, and control of cell morphology
	although MYH9 and MYH10 form filaments with similar properties, MYH14 forms filaments that are less well suited to roles such as tension maintenance within the cell

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	ATP binding

protein	interacting with cytoskeletal actin in absence of ATP
	SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, CEP131), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome
	LIMCH1 plays a positive role in regulation of MYH14 activity through effects on myosin regulatory light chain (MRLC) during cell migration

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DFNA4 , PNMHH

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS