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FLASH GENE

Symbol

ITIH3

contributors: mct/npt - updated : 18-11-2009

HGNC name	inter-alpha (globulin) inhibitor H3
HGNC id	6168

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002217 22 - 3037 NP_002208 - 890 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive esophagus           liver       highly Lymphoid/Immune spleen         Reproductive female system ovary         male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a VWFA domain

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

ITIH family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm

basic FUNCTION	trypsin inhibitor
	regulaing the localization, synthesis and
	degradation of hyaluronan which are essential to cells undergoing biological processes
	contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function       --low   in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008)

Susceptibility

to myocardial infarction to bipolar disorder

Variant & Polymorphism SNP	significant association between myocardial infarction and a SNP in exon 2

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS