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FLASH GENE
Symbol THAP11 contributors: mct/pgu - updated : 09-12-2014
HGNC name THAP domain containing 11
HGNC id 23194
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a THAP domain associated with sequence-specific DNA binding and epigenetic silencing of gene expression
  • two poly-Ala domains
  • a poly-Gln domain
    • HOMOLOGY
    interspecies ortholog to murine Thap11
    ortholog to rattus thap11_predicted
    Homologene
    FAMILY
  • THAP11 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • essential factor underlying embryogenesis and embryonic stem cell pluripotency
  • may be an endogenous physiologic regulator of cell proliferation
  • functions as a cell growth suppressor by negatively regulating the expression of MYC
  • with others THAP proteins could play a major role in targeting genes to promote transcription regulation through interactions with protein complexes associated to chromatin remodelling
  • essential role for the self-renewal of embryonic stem cells
  • novel role of THAP11 in CD44 alternative splicing and hepatoma invasion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex THAP11/HCFC1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells
  • THAP11/ZNF143/HCFC1 complex is a critical component of the transcriptional regulatory network governing cell proliferation
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • binds directly to HCFC1, a key transcriptional regulator (association with HCFC1 suggests an epigenetic mechanism of gene repression in pluripotent cells)
  • interacts with host cell factor-1 HCFC1, a key transcriptional regulator associated to chromatin remodelling
  • is a novel physiological binding partner of PCBP1
  • HCFC1 serves as a scaffold protein, bridging interactions between transcription factors, including THAP11 and ZNF143, and transcriptional coregulators
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for neuropsychiatric disease, due to triplet repeats
    Marker
    Therapy target
    ANIMAL & CELL MODELS