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FLASH GENE
Symbol ITIH1 contributors: mct/npt - updated : 07-09-2009
HGNC name inter-alpha (globulin) inhibitor H1
HGNC id 6166
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunespleen    
Reproductivefemale systembreastmammary gland  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VWFA domain
    • HOMOLOGY
    Homologene
    FAMILY
  • ITIH family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein
  • contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008)
    Susceptibility
  • to bipolar disorder
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS