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FLASH GENE

Symbol

ITIH1

contributors: mct/npt - updated : 07-09-2009

HGNC name	inter-alpha (globulin) inhibitor H1
HGNC id	6166

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002215 22 - 2910 NP_002206 - 911 - Scott (2009)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune spleen         Reproductive female system breast mammary gland

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a VWFA domain

HOMOLOGY

Homologene

FAMILY

ITIH family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein
	contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008)

Susceptibility

to bipolar disorder

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS