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FLASH GENE
Symbol ITIH1 contributors: mct/npt - updated : 07-09-2009
HGNC name inter-alpha (globulin) inhibitor H1
HGNC id 6166
Location 3p21.1      Physical location : 52.811.607 - 52.826.077
Synonym name
  • inter-alpha (globulin) inhibitor, H1 polypeptide
  • inter-alpha- (protein HC),heavy chain 1
  • serum-derived hyaluronan-associated protein
  • ITI heavy chain H1
    • Synonym symbol(s) H1P, IATIH, ITIH, MGC126415, IGHEP1, SHAP
    DNA
    TYPE functioning gene
    STRUCTURE 14.47 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2910 - 911 - Scott (2009)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunespleen    
    Reproductivefemale systembreastmammary gland  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a VWFA domain
    • HOMOLOGY
    Homologene
    FAMILY
  • ITIH family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein
  • contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in multiple solid tumors, including breast, colon and lung cancer (Hamm 2008)
    Susceptibility
  • to bipolar disorder
    • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS