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FLASH GENE
Symbol SPRR4 contributors: - updated : 26-10-2004
HGNC name small proline rich protein 4
HGNC id 23173
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a gln/lys rich domain
  • a pro-rich central repetitive domain
    • HOMOLOGY
    Homologene
    FAMILY cornifin (SPRR) family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text translocates in a calcium-dependent manner to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes
    basic FUNCTION
  • cross-link envelope protein of keratinocytes
  • involved in UV-induced cornified envelope assembly
  • part of an adaptive response to environmental stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by UV-light
    Other gradual increased expression from the basal to the granular layer
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS