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FLASH GENE

Symbol

SPRR4

contributors: - updated : 26-10-2004

HGNC name	small proline rich protein 4
HGNC id	23173

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

UV-light

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum spinosum   Epithelial barrier lining epidermis stratum granulosum   Epithelial barrier lining epidermis stratum basale

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a gln/lys rich domain
	a pro-rich central repetitive domain

HOMOLOGY

Homologene

FAMILY

cornifin (SPRR) family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	translocates in a calcium-dependent manner to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes

basic FUNCTION	cross-link envelope protein of keratinocytes
	involved in UV-induced cornified envelope assembly
	part of an adaptive response to environmental stress

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

UV-light

Other

gradual increased expression from the basal to the granular layer

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS