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FLASH GENE
Symbol SYT14 contributors: mct - updated : 17-10-2016
HGNC name synaptotagmin 14
HGNC id 23143
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C2 domain
  • a single transmembrane domain at the N-terminus
  • a putative fatty-acylation site just downstream of the transmembrane domain
    • mono polymer oligo
    HOMOLOGY
    interspecies homolog to murine Syt14
    homolog to drosophila Strep14
    Homologene
    FAMILY synaptotagmin family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • required for synaptic vesicle and secretory granule exocytosis
  • may be involved in membrane trafficking in specific tissues outside the brain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other Ca2+ dependent
    ASSOCIATED DISORDERS
    corresponding disease(s) SCAR11
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS