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FLASH GENE

Symbol

SYT14

contributors: mct - updated : 17-10-2016

HGNC name	synaptotagmin 14
HGNC id	23143

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	233.15 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001256006 9 - 5213 NP_001242935 - 517 - 2007 17304550 NM_001146261 9 - 5186 NP_001139733 - 619 - 2007 17304550 NM_001146264 9 - 5129 NP_001139736 - 600 - 2007 17304550 NM_001146262 9 - 5069 NP_001139734 - 574 - 2007 17304550 NM_153262 8 - 5008 NP_694994 - 555 - 2007 17304550

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland         Nervous brain limbic system hippocampus       brain basal nuclei caudate nucleus       brain basal nuclei corpus callosum     Reproductive female system ovary       Respiratory respiratory tract trachea       Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one C2 domain
	a single transmembrane domain at the N-terminus
	a putative fatty-acylation site just downstream of the transmembrane domain

mono polymer

oligo

HOMOLOGY

interspecies	homolog to murine Syt14
	homolog to drosophila Strep14

Homologene

FAMILY

synaptotagmin family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	required for synaptic vesicle and secretory granule exocytosis
	may be involved in membrane trafficking in specific tissues outside the brain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

exocytosis transport

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

Ca2+ dependent

ASSOCIATED DISORDERS

corresponding disease(s)

SCAR11

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS