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FLASH GENE
Symbol SYT14 contributors: mct - updated : 17-10-2016
HGNC name synaptotagmin 14
HGNC id 23143
Corresponding disease
SCAR11 spinocerebellar ataxia, autosomal recessive 11
Location 1q32.2      Physical location : 210.111.537 - 210.337.631
Synonym symbol(s) sytXIV, FLJ34198
DNA
TYPE functioning gene
STRUCTURE 233.15 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC391157 1 similar to GRB2-related adaptor protein LOC391158 1 similar to Transcription factor DP-1 (E2F dimerization partner 1) (DRTF1-polypeptide-1) (DRTF1) LOC91170 1q32.2 hypothetical gene supported by AK002208 CAMK1G 1q32-q41 calcium/calmodulin-dependent protein kinase IG LAMB3 1q32 laminin, beta 3 G0S2 1q32.2-q41 laminin, beta 3 HSD11B1 1q32-q41 hydroxysteroid (11-beta) dehydrogenase 1 ADORA2BP 1q32 adenosine A2b receptor pseudogene T3JAM 1q32.3-q41 TRAF3-interacting Jun N-terminal kinase (JNK)-activating modulator FLJ25078 1q32.2 hypothetical protein FLJ25078 IRF6 1q32.3-q41 interferon regulatory factor 6 MGC29875 1q32.2 hypothetical protein MGC29875 SYT14 1q32.2 synaptotagmin XIV DJ667H12.2 1q32.1-q41 hypothetical protein DJ667H12.2 LOC339397 1q32.2 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein LOC199827 1q32.2 ribonuclease H1 pseudogene FLJ10724 1q32 melanoma antigen recognized by T cells 2 KCNH1 1q32-q41 potassium voltage-gated channel, subfamily H (eag-related), member 1 LOC388733 1 similar to 40S ribosomal protein S25 LOC388734 1 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) FLJ10876 1q32.3 hypothetical protein FLJ10876 TRAF5 1q32 TNF receptor-associated factor 5 MGC14801 1q32.3 hypothetical protein MGC14801 LOC391160 1 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) C1orf36 1q32.3 chromosome 1 open reading frame 36 SLC30A1 1q32-q41 solute carrier family 30 (zinc transporter), member 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 5213 - 517 - 2007 17304550
9 - 5186 - 619 - 2007 17304550
9 - 5129 - 600 - 2007 17304550
9 - 5069 - 574 - 2007 17304550
8 - 5008 - 555 - 2007 17304550
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Nervousbrainlimbic systemhippocampus  
 brainbasal nucleicaudate nucleus  
 brainbasal nucleicorpus callosum  
Reproductivefemale systemovary   
Respiratoryrespiratory tracttrachea   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C2 domain
  • a single transmembrane domain at the N-terminus
  • a putative fatty-acylation site just downstream of the transmembrane domain
  • mono polymer oligo
    HOMOLOGY
    interspecies homolog to murine Syt14
    homolog to drosophila Strep14
    Homologene
    FAMILY synaptotagmin family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • required for synaptic vesicle and secretory granule exocytosis
  • may be involved in membrane trafficking in specific tissues outside the brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other Ca2+ dependent
    ASSOCIATED DISORDERS
    corresponding disease(s) SCAR11
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS