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FLASH GENE
Symbol CXCL10 contributors: mct - updated : 22-01-2016
HGNC name chemokine (C-X-C motif) ligand 10
HGNC id 10637
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cxcl10
Homologene
FAMILY
  • intercrine alpha (chemokine CxC) family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • interferon gamma, T cells and NK cells chemoattractant
  • chemotactic for monocytes and T-lymphocytes
  • inducing cell death in neurons through calcium dysregulation
  • plays an important role in triggering beta cell destruction and diabetes
  • regulates liver inflammation response against ischemia/reperfusion injury
  • recruit donor-reactive T cells to the allograft, but is antagonistic costimulation molecule with CXCL9 during the priming of alloreactive T cell effectors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding CXCR3 (Ligand of CXCR3)
  • binding partner for TLR4 and a signal toward beta cell failure in diabetes
  • plays a central role in LCN2-induced cell migration( key role for LCN2-CXCL10 axis in cell migration and reactive astrocytosis following brain inflammation or injury)
  • KLF2 negatively controls the ability of CD8 T cells to respond to the CXCR3 ligand CXCL10
  • CUX1 downregulates several NFKB-regulated chemokines such as CXCL10
    • cell & other
    REGULATION
    Other cleavage of the N-terminal two residues by DPP8
    IL1A regulates CXCL1, CXCL10, and ICAM1 in network form in oral keratinocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in several neurodegenerative diseases, including multiple sclerosis, Alzheimer disease and HIV-associated dementia
    Susceptibility susceptibility to tuberculosis (TB)
    Variant & Polymorphism SNP new potential protective SNP (-135G>A) for TB is identified in the promoter of chemokine gene, CXCL-10
    Candidate gene
    Marker
    Therapy target
  • targeting CXCL10 may provide a novel therapeutic means to ameliorate liver ischemia/reperfusion injury in clinics
    • ANIMAL & CELL MODELS