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FLASH GENE

Symbol

CXCL10

contributors: mct - updated : 22-01-2016

HGNC name	chemokine (C-X-C motif) ligand 10
HGNC id	10637

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	2.38 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D4S35 - D4S1 - MT2P1 - GC - ALB /AFP AFP - IL8 - CXCL1 /PPBP /PF4 - CXCL5 /CXCL6 - CXCL11 - CXCL10 - CXCL10 - CXCL9 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001565 4 - 1184 NP_001556 - 98 - 1996 8976378

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           pharynx       highly Endocrine parathyroid       highly Reproductive female system uterus     highly   male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Cxcl10

Homologene

FAMILY

intercrine alpha (chemokine CxC) family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	interferon gamma, T cells and NK cells chemoattractant
	chemotactic for monocytes and T-lymphocytes
	inducing cell death in neurons through calcium dysregulation
	plays an important role in triggering beta cell destruction and diabetes
	regulates liver inflammation response against ischemia/reperfusion injury
	recruit donor-reactive T cells to the allograft, but is antagonistic costimulation molecule with CXCL9 during the priming of alloreactive T cell effectors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding CXCR3 (Ligand of CXCR3)
	binding partner for TLR4 and a signal toward beta cell failure in diabetes
	plays a central role in LCN2-induced cell migration( key role for LCN2-CXCL10 axis in cell migration and reactive astrocytosis following brain inflammation or injury)
	KLF2 negatively controls the ability of CD8 T cells to respond to the CXCR3 ligand CXCL10
	CUX1 downregulates several NFKB-regulated chemokines such as CXCL10

cell & other

REGULATION

Other	cleavage of the N-terminal two residues by DPP8
	IL1A regulates CXCL1, CXCL10, and ICAM1 in network form in oral keratinocytes

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in several neurodegenerative diseases, including multiple sclerosis, Alzheimer disease and HIV-associated dementia

Susceptibility

susceptibility to tuberculosis (TB)

Variant & Polymorphism SNP	new potential protective SNP (-135G>A) for TB is identified in the promoter of chemokine gene, CXCL-10

Candidate gene
Marker
Therapy target	targeting CXCL10 may provide a novel therapeutic means to ameliorate liver ischemia/reperfusion injury in clinics

ANIMAL & CELL MODELS