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FLASH GENE
Symbol ANGPTL6 contributors: mct - updated : 14-02-2018
HGNC name angiopoietin-like 6
HGNC id 23140
Location 19p13.2      Physical location : 10.203.012 - 10.213.425
Synonym name
  • angiopoietin-related protein 5
  • angiopoietin growth factor
    • Synonym symbol(s) ARP5, AGF
    DNA
    TYPE functioning gene
    STRUCTURE 13.86 kb     6 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1857 - 470 - 2006 16806062
    6 - 1779 - 470 - 2006 16806062
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouthtongue   
    reproductiveepididymis    
    Reproductivefemale systemplacenta  specific
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil domain
  • a 20 aa signal peptide
  • a linker region,
  • a C-terminal fibrinogen-like domain
    • conjugated GlycoP
    isoforms Precursor a mature protein of 450 aa
    HOMOLOGY
    interspecies homolog to rattus Angptl6 (76.98 pc)
    homolog to murine Angptl6 (76.37 pc)
    Homologene
    FAMILY
  • angiopoietin family
  • vascular endothelial growth factor family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • inducing sprouting in endothelial cells through an autocrine and paracrine action
  • may promote epidermal proliferation, remodeling and regeneration
  • playing a role in the wound healing process
  • hepatocyte-derived circulating factor counteracting obesity and related insulin resistance
  • may promote the chemotactic activity of endothelial cells
  • inducing neovascularization
  • may counteract high-fat diet-induced obesity
  • related insulin resistance through increased energy expenditure
  • supporting adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins
  • circulating pro-angiogenic factor mainly secreted from the liver, which increases endothelial permeability and stimulates endothelial cell migration
  • ANGPTL3, 4, and ANGPTL6/angiopoietin-related growth factor also appear to directly regulate lipid, glucose, and energy metabolism independently of angiogenic effects
  • ANGPTL3, -4 and ANGPTL6/angiopoietin-related growth factor (AGF) directly regulate lipid, glucose and energy metabolism independent of angiogenic effects
  • placenta is an important source of circulating ANGPTL6 during pregnancy
  • ANGPTL6 is a key regulator of MYOCD activity
  • is a novel metabolic regulator that modulates energy expenditure as well as glucose and lipid metabolism
  • possible association between thyroid function and ANGPTL6 levels
  • likely could trigger cerebrovascular lesions when combined with other risk factors such as hypertension
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • growth factors largely specific for vascular endothelium
  • angiogenesis
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ANGPTL6 is a key regulator of MYOCD activity
  • ANGPTL6-mediated increase in PPARA expression resulted in increased FGF21 expression, thereby promoting beta-oxidation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in obesity and insulin resistance
    constitutional     --over  
    in patients with overt hypothyroidism than in the other subjects
    constitutional     --over  
    serum ANGPTL6 increased in polycystic ovary syndrome
    constitutional     --over  
    maternal ANGPTL6 serum levels are significantly and paradoxically higher in preeclampsia during pregnancy
    Susceptibility to Intracranial aneurysms (IAs)
    Variant & Polymorphism other
  • rare coding variants in ANGPTL6 are causally related to familial forms of IA
    • Candidate gene potential target for treatmenf of obesity and insulin resistance
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Angptl6 -/- mice (Oike, 2005)