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FLASH GENE

Symbol

INHBB

contributors: mct/npt - updated : 13-11-2009

HGNC name	inhibin, beta B
HGNC id	6067

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     repression of the entire 4-Mb band of chromosome 2q.14.2, associated with global methylation of histone H3 Lys9 in colorectal cancer tumoral     --low   in pheochromocytoma constitutional     --over   in adipocytes, and adipose tissue INHBB mRNA levels correlated to metabolic risk factors (Sjoholm 2006) constitutional     --over   the exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis (Mahmoud 2005)

Susceptibility

Variant & Polymorphism

Candidate gene	marker of Sertoli cell function and spermatogenesis (Mahmoud 2005)
Marker
Therapy target

ANIMAL & CELL MODELS