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FLASH GENE
Symbol INHBB contributors: mct/npt - updated : 13-11-2009
HGNC name inhibin, beta B
HGNC id 6067
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , heteromer , dimer
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Inhbb
homolog to C.elegans T25F10.2
Homologene
FAMILY
  • TGF-beta family
  • BMP family
    • CATEGORY signaling hormone growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating gonadal stromal cell proliferation negatively
  • having tumour-suppressor activity
  • may have local effects in adipose tissue and thereby influence obesity and its comorbidities (Carlsson 2009)
  • negatively regulate the release of FSH from the anterior pituitary (Makanji 2009)
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • dimerizing with INHA to form inhibin a pituitary FSH secretion inhibitor
  • homodimerizing or heterodimerizing with INHBA to form activin B or respectively AB,stimulating FSH secretion
  • homodimerization of two INHBB subunits results in formation of activin B (Carlsson 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • negative regulator of gonadal stromal cell proliferation
    • REGULATION
    induced by BMP6, in granulosa cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    repression of the entire 4-Mb band of chromosome 2q.14.2, associated with global methylation of histone H3 Lys9 in colorectal cancer
    tumoral     --low  
    in pheochromocytoma
    constitutional     --over  
    in adipocytes, and adipose tissue INHBB mRNA levels correlated to metabolic risk factors (Sjoholm 2006)
    constitutional     --over  
    the exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis (Mahmoud 2005)
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker of Sertoli cell function and spermatogenesis (Mahmoud 2005)
    Marker
    Therapy target
    ANIMAL & CELL MODELS