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FLASH GENE
Symbol INHBB contributors: mct/npt - updated : 13-11-2009
HGNC name inhibin, beta B
HGNC id 6067
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal glandmedulla   
endocrinebraindiencephalonpituitary  
Endocrinethyroid   highly
Nervousnervecranial nerve  highly
Reproductivemale systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Nervousautonomous   
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoptic nerve
not specificadipocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , heteromer , dimer
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Inhbb
homolog to C.elegans T25F10.2
Homologene
FAMILY
  • TGF-beta family
  • BMP family
  • CATEGORY signaling hormone growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating gonadal stromal cell proliferation negatively
  • having tumour-suppressor activity
  • may have local effects in adipose tissue and thereby influence obesity and its comorbidities (Carlsson 2009)
  • negatively regulate the release of FSH from the anterior pituitary (Makanji 2009)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • dimerizing with INHA to form inhibin a pituitary FSH secretion inhibitor
  • homodimerizing or heterodimerizing with INHBA to form activin B or respectively AB,stimulating FSH secretion
  • homodimerization of two INHBB subunits results in formation of activin B (Carlsson 2009)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • negative regulator of gonadal stromal cell proliferation
  • REGULATION
    induced by BMP6, in granulosa cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    repression of the entire 4-Mb band of chromosome 2q.14.2, associated with global methylation of histone H3 Lys9 in colorectal cancer
    tumoral     --low  
    in pheochromocytoma
    constitutional     --over  
    in adipocytes, and adipose tissue INHBB mRNA levels correlated to metabolic risk factors (Sjoholm 2006)
    constitutional     --over  
    the exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis (Mahmoud 2005)
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker of Sertoli cell function and spermatogenesis (Mahmoud 2005)
    Marker
    Therapy target
    ANIMAL & CELL MODELS