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FLASH GENE
Symbol GSTO2 contributors: mct - updated : 09-12-2014
HGNC name glutathione S-transferase omega 2
HGNC id 23064
Location 10q25.1      Physical location : 106.028.630 - 106.059.175
Synonym name glutathione-S-transferase-like protein
EC.number 2.5.1.18
DNA
TYPE functioning gene
STRUCTURE 36.53 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ARL3 10q24.1 ADP-ribosylation factor-like 3 SFXN2 10q24.32 sideroflexin 2 C10orf26 10q24.33 chromosome 10 open reading frame 26 CYP17A1 10q24.3 cytochrome P450, family 17, subfamily A, polypeptide 1 LOC390000 10 similar to Tebp-pending-prov protein C10orf32 10q24.33 chromosome 10 open reading frame 32 CYT19 10q24.33 Cyt19 protein CNNM2 10q24.32 cyclin M2 NT5C2 10q24.32 5'-nucleotidase, cytosolic II LOC90470 10q24.33 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) INA 10q24.33 internexin neuronal intermediate filament protein, alpha RNF134 10q24.33 ring finger protein 134 TAF5 10q24 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa MGC14697 10q24.33 upregulated during skeletal muscle growth 5 LOC51063 10pter-q26.12 hypothetical protein LOC51063 LOC119395 10q24.33 hypothetical protein LOC119395 NEURL 10q25.1 neuralized-like (Drosophila) SH3MD1 10q24.33 SH3 multiple domains 1 FLJ22559 10q25.1 hypothetical protein FLJ22559 SLK 10q24.1-q25.2 SNF1 sucrose nonfermenting like kinase (yeast) COL17A1 10q24.3 collagen, type XVII, alpha 1 LOC119392 10q25.1 LOC119392 FLJ22944 10q25.1 hypothetical protein FLJ22944 GSTO1 10q24.33 glutathione S-transferase omega 1 GSTO2 10q25.1 glutathione S-transferase omega 2 KIAA1754 10q25.1 KIAA1754 protein LOC387710 10 LOC387710 FLJ35908 10q25.1 hypothetical protein FLJ35908 SORCS3 10q22-q26 hypothetical protein FLJ35908
regionally located separated of GSTO1 by 7.5kb
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1546 - 243 - 2005 15942673
6 - 1444 - 209 - 2005 15942673
6 - 981 - 215 - 2005 15942673
4 - 879 - 181 - 2005 15942673
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver    
Endocrinepancreas   highly
 parathyroid   highly
Reproductivemale systemprostate   
 male systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • thioredoxin-like domains
  • a glutathione binding site where glutathione can form a disulfide bond with a conserved active site cysteine residue positioned near the N-terminal end of helix 1
  • HOMOLOGY
    intraspecies homolog to GSTO1
    Homologene
    FAMILY GST superfamily, omega family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having glutathione transferase activity
  • may play an important role in cellular signaling
  • two isozymes (GSTO1 and GSTO2) have significant DHA reductase (DHAR) activity
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to ovarian cancer
  • to late onset Alzheimer disease (Webster 2009)
  • Variant & Polymorphism other polymorphism associated with the risk of ovarian cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS