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FLASH GENE
Symbol DPEP2 contributors: mct - updated : 28-03-2019
HGNC name dipeptidase 2
HGNC id 23028
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure disulfide-linked
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Dpep2
Homologene
FAMILY peptidase family M19
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
text GPI-anchored
basic FUNCTION
  • hydrolyzes a wide range of dipeptides
  • implicated in the renal metabolism of glutathione and its conjugates
  • converts leukotriene d4 to leukotriene e4; it may play an important role in the regulation of leukotriene activity
  • cleaves leukotriene D4 (LTD4) but not cystinyl-bis-glycine
  • DPEP2 could protect against Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) by acting as a suppressor of macrophage inflammation
    • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS