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FLASH GENE
Symbol COL23A1 contributors: mct - updated : 05-09-2016
HGNC name collagen, type XXIII, alpha 1
HGNC id 22990
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a long amino-terminal non collagenous domain (NC1)
  • a transmembrane region
  • three collagenous domains
  • a suitable basic motif KIRTAR
    • mono polymer homomer , dimer , trimer
    HOMOLOGY
    interspecies homolog to murine Col23a1
    intraspecies homolog to Col13
    homolog to Col25
    Homologene
    FAMILY collagen superfamily
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • type II orientated transmembrane collagen
  • either as full-length cell surface anchored molecules or as shed soluble ectodomains
  • localized in lipid rafts in the plasma membrane and ectodomain shedding is altered by a cholesterol-dependent mechanism
    • basic FUNCTION
  • regulation of transcription DNA dependent
  • potential role for collagen XXIII in mediating metastasis by facilitating cell-cell and cell-matrix adhesion as well as anchorage-independent cell growth
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms homotrimers consisting of a short intracellular domain, a single-pass transmembrane domain and three extracellular collagen domains interrupted by short noncollagenous sequences
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • directly interacts with integrin ITGA2/ITGB1 and is sufficient to induce integrin ITGA2/ITGB1 -dependent attachment and spreading of keratinocytes
    • cell & other
    REGULATION
    Other cleaved by furin protease activity, leading to a soluble form of 60kDa that forms a homotrimer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for non-small cell lung cancer (NSCLC) (
    • Therapy target
    ANIMAL & CELL MODELS