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FLASH GENE

Symbol

IL1B

contributors: mct - updated : 02-06-2019

HGNC name	interleukin 1, beta
HGNC id	5992

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in multiple myeloma constitutional     --over   mRNA levels of NLRC4, NLRP12, and IL1B were significantly upregulated in Kawasaki disease (KD) patients compared to the controls

Susceptibility

susceptibility factor to inflammatory bowel diseases and temporal lobe epilepsy susceptibility to schizophrenia and bipolar disorder to bone involvement in celiac disease to Chronic kidney disease (CKD) and periodontitis (PD) to diabetes

Variant & Polymorphism SNP , other	SNP 511 susceptibility to asthma exclusively in males and to schizophrenia and bipolar disorder
	increased in febrile seizures
	gene cluster polymorphisms are related to velocity of tooth translation
	IL1B rs1143634(G-->A) was associated with higher blood glucose than the major allele: 5.37, 5.41, and 5.48 mmol/liter for the GG, AG, and AA genotypes, respectively
	carriers of allele T of the interleukin-1beta gene (IL1B-511T) had a significantly lower bone mass at the total skeleton level in celiac disease
	association of IL1B alleles with susceptibility to CKD and PD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS