| protein
| upregulating SLAM (signaling lymphocyte activation molecule) on mature dendritic cells |
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upregulating ADAMTS1 in stromal cells |
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IL1A stimulates cardiac myofibroblasts (CMF) to express IL1B, TNF, and IL6 via specific signaling pathways  |
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IL1B induced SMAD7 negatively regulates gastrin expression |
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IL1B, IL1A both bind to the same IL1 receptor (IL1R1) and are potent proinflammatory cytokines |
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IL1B directly binds IL1A, thus identifying IL1B as a shuttle for another proinflammatory cytokine |
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a major proinflammatory cytokine, IL1B, can facilitate local progesterone metabolism in a cell type critical for maintaining uterine cervical structure via regulating expression of AKR1C1 and AKR1C2 |
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IL1B regulates FOXO1 activity through a novel SMPD3-dependent pathway |
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IL1B counteracts the AKT1-mediated insulin signals by increasing the overall cellular FOXO1 content and augmenting its nuclear localization |
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NLRP3 is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory cytokine IL1B by activating CASP1 |
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TLR3 stimulation in keratinocytes induces a CASP4 dependent release of pro-IL1B, but further processing to active IL1B is limited |
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secretion of IL1A, IL1B, IL12B, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3 |
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NFKB1 may be involved in IL1B-induced activation of ADAMTS9 in human chondrocytes |
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in the presence of CASP1, CASP8 acts as a positive modulator of the NLRP3-dependent CASP1 signaling cascades that drive both IL1B production and pyroptotic death |
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PLIN2 inhibits insulin& |
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8209;induced glucose uptake by activating NLRP3, CASP1 and IL1B, leading to a decreased IRS1 expression |
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CASP4 and caspase-5 mediate IL1A and IL1B release from human monocytes after lipopolysaccharide (LPS) stimulation |
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IL36G expression was induced by the combination of IL1B and TNF via activation of MAPKs and transcription factors, NFKB1 and JUN in colonic myofibroblasts |
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PGAM5 is a mitochondrial phosphatase that has been reported to function downstream of RIPK3 to promote necroptosis and IL1B secretion |
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IL1B regulates NOTCH1 and NOTCH4 activity in opposite directions, consistent with a selective targeting of NOTCH1 in inflamed endothelium |
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NLRC4-driven IL1B production is critical for the progression of Diabetic Nephropathy |
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new roles for CD14 and IL1B linking inflammatory dendritic cells to IL17A production in memory CD4+ T cells |
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CASP4 physically interacts with CASP1 and is believed to be a proinflammatory caspase that can induce the inflammatory form of programmed cell death (pyroptosis) and the release of mature interleukin IL1B |
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IL1B increases AMTN gene transcription in gingival epithelial cells mediated through CEBP1, CEBP2, and YY1 elements in the human AMTN gene promoter |
| Variant & Polymorphism
SNP
, other
| SNP 511 susceptibility to asthma exclusively in males and to schizophrenia and bipolar disorder |
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increased in febrile seizures |
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gene cluster polymorphisms are related to velocity of tooth translation |
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IL1B rs1143634(G-->A) was associated with higher blood glucose than the major allele: 5.37, 5.41, and 5.48 mmol/liter for the GG, AG, and AA genotypes, respectively |
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carriers of allele T of the interleukin-1beta gene (IL1B-511T) had a significantly lower bone mass at the total skeleton level in celiac disease |
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association of IL1B alleles with susceptibility to CKD and PD |
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