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FLASH GENE
Symbol IRF2BP1 contributors: mct/npt/pgu - updated : 04-04-2012
HGNC name interferon regulatory factor 2 binding protein 1
HGNC id 21728
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal zinc finger
  • a C-terminal RING finger domain of the C3HC4 type
    • HOMOLOGY
    interspecies homolog to murine Irf2bp1
    Homologene
    FAMILY
  • IRF2BP family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • corepressor for IRF2
  • can inhibit both enhancer-ativated and basal transcription in an IRF2-dependent manner
  • repressed ATF2-mediated transcriptional activation from a CRE-containing promoter
  • IRF2BP1 and EAP1 (enhanced at puberty 1) are important components of the DIF-1 complex mediating both complex stability and transcriptional repression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IRF2 (transcriptional corepressor of IRF2)
  • with JDP2 (enhanced the polyubiquitination of JDP2)
  • interaction of IRF2BP2, IRF2BP1, and EAP1 occurs through the conserved C4 zinc fingers of these proteins, and forms DIF-1 complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS