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FLASH GENE
Symbol HCP5 contributors: mct - updated : 30-03-2021
HGNC name HLA complex P5
HGNC id 21659
Corresponding disease
PSORS1 familial psoriasis 1
Location 6p21.33      Physical location : 2.761.726 - 31.433.584
Synonym name
  • MHC class I region ORF
  • protein P5-1
  • HLA complex protein P5
    • Synonym symbol(s) D6S2650E, P5-1
    DNA
    TYPE small rna
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type untranslated
    EXPRESSION
    Rna function
  • mechanically, HCP5 was found to be activated by the transcription factor SP1
  • is a novel transcriptional activator of MSH5
  • MSH5 is the target of HCP5 during DNA double-strand breaks (DSBs) repair
  • HCP5 regulated MSH5 expression and Granulosa cells function through direct binding with YB1 and modulating its subcellular localization
    • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PSORS1
    Susceptibility psoriasis and psoriasis arthritis
    Variant & Polymorphism SNP rs2395029 encoding the G2V polymorphism; same variant associated with low viral set point following HIV infection
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS