Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
| amplification
|  
|  
|
in various cancers | constitutional
|  
|  
| --low
|  
|
causes a defect in epithelial Ca2+-dependent chloride transport | tumoral
|  
|  
| --over
|  
|
in gastrointestinal stromal tumors | constitutional
|  
|  
| --over
|  
|
epithelial expression is increased in asthmatics, particularly in secretory cells | tumoral
|  
|  
| --over
|  
|
in several cancers including esophageal cancer | tumoral
|  
|  
| --over
|  
|
in many cancers, including gastrointestinal stromal tumors, gastric cancer, head and neck squamous cell carcinoma (HNSCC), colon cancer, pancreatic ductal adenocarcinoma, and esophageal cancer | constitutional
|  
|  
|  
| loss of function
|
selective ANO1 inhibition can reduce pain sensation | constitutional
|  
|  
|  
| loss of function
|
resulted in reduced nephron number and, subsequently, albuminuria and tubular damage | |