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FLASH GENE
Symbol ANO1 contributors: mct/pgu - updated : 22-01-2019
HGNC name anoctamin 1, calcium activated chloride channel
HGNC id 21625
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   amplification    
in various cancers
constitutional     --low  
causes a defect in epithelial Ca2+-dependent chloride transport
tumoral     --over  
in gastrointestinal stromal tumors
constitutional     --over  
epithelial expression is increased in asthmatics, particularly in secretory cells
tumoral     --over  
in several cancers including esophageal cancer
tumoral     --over  
in many cancers, including gastrointestinal stromal tumors, gastric cancer, head and neck squamous cell carcinoma (HNSCC), colon cancer, pancreatic ductal adenocarcinoma, and esophageal cancer
constitutional       loss of function
selective ANO1 inhibition can reduce pain sensation
constitutional       loss of function
resulted in reduced nephron number and, subsequently, albuminuria and tubular damage
Susceptibility
Variant & Polymorphism
Candidate gene abundance of TMEM16A in tumours suggesting that tmem16A proteins participate in tumorigenesis
Marker
Therapy target
SystemTypeDisorderPubmed
respiratoryCF (mucoviscidosis) 
may provide the basis for novel pharmacological strategies for the treatment of cystic fibrosis, because Ca2+-dependent Cl- channels may be activated to compensate for defective CFTR Cl- channel function
respiratoryCF (mucoviscidosis) 
may provide the basis for novel pharmacological strategies for the treatment of cystic fibrosis, because Ca2+-dependent Cl- channels may be activated to compensate for defective CFTR Cl- channel function
digestiveliver 
may be a potential target to modulate bile formation in the treatment of cholestatic liver disorders
respiratory  
ANO1-CLCA4 blockers, including those identified here, may positively impact multiple causes of asthma symptoms
respiratoryCF (mucoviscidosis) 
pharmacological activation of TMEM16A offers a potential therapeutic strategy to reduce the inflammation of CF airway epithelia
cancer  
pharmacological inhibition of ANO1 induces apoptosis and cell cycle arrest at G1 phase in different types of epithelium-originated cancer cells
cancerdigestive 
is a potential drug target for treating metastatic colorectal carcinoma
ANIMAL & CELL MODELS
knockdown of mouse Ano1 markedly reduced native calcium-activated chloride currents as well as saliva production in mice