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FLASH GENE
Symbol CHAF1B contributors: SGE/npt - updated : 26/04/2010
HGNC name chromatin assembly factor 1, subunit B (p60)
HGNC id 1911
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 7 WD-40 repeat domains
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Chaf1b (84.4pc)
    homolog to rattus Chaf1b (84.8pc)
    Homologene
    FAMILY
  • WD-repeat HIR1 family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text normally found in the nucleus except during mitosis, when it is released into the cytoplasm
    basic FUNCTION
  • required for the assembly of histone octamers onto newly-replicated DNA
  • p60 subunit required for chromatin assembly after replication and may also be involved in DNA repair
  • essential factor not only for S-phase-specific chromatin assembly but also for proliferating cell viability
  • recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex composed of p50, p60, and p150, active complex in G1, S and G2 phases
  • associating with SETDB1-CBX5 chaperone complex and monomethylating K9 on non nucleosomal histone H3, thus providing H3K9me1 for subsequent trimethylation by SUV39H1/H2 in pericentric regions (Loyola 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other hyperphosphorylated during mitosis and released in the cytoplasm
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene overexpression of CAF-1/p60 characterized prostatic cancers with a worse prognosis (Staibano 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS