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FLASH GENE

Symbol

RBM24

contributors: mct - updated : 20-09-2014

HGNC name	RNA binding motif protein 24
HGNC id	21539

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RNA binding region
	a RNA recognition motif required for binding to CDKN1A transcript and subsequently for inducing CDKN1A expression

HOMOLOGY

interspecies

homolog to murine LOC380843

Homologene

FAMILY

RRM superfamily

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	plays a crucial role in myogenic differentiation at least in part through a myogenin-dependent post-transcriptional regulatory pathway
	role of the tissue-specific RNA-binding protein (RBP) RBM24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility
	RNA-binding protein and target gene of the TP53 protein, that can regulate CDKN1A expression via mRNA stability
	is a novel player in the TP53 pathway, which may be explored to restore proper cell cycle control in TP53-deficient tumors via CDKN1A
	is required for skeletal muscle differentiation
	is a novel key regulator of the myogenic differentiation program during vertebrate development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein

is a novel regulator of TP63 via mRNA stability

cell & other

REGULATION

induced by

induced by DNA damage and MDM2 inhibitor Nutlin-3

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   implicated in cardiomyopathy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS