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FLASH GENE
Symbol RBM24 contributors: mct - updated : 20-09-2014
HGNC name RNA binding motif protein 24
HGNC id 21539
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Mus musculusFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte Mus musculusFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA binding region
  • a RNA recognition motif required for binding to CDKN1A transcript and subsequently for inducing CDKN1A expression
    • HOMOLOGY
    interspecies homolog to murine LOC380843
    Homologene
    FAMILY RRM superfamily
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • plays a crucial role in myogenic differentiation at least in part through a myogenin-dependent post-transcriptional regulatory pathway
  • role of the tissue-specific RNA-binding protein (RBP) RBM24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility
  • RNA-binding protein and target gene of the TP53 protein, that can regulate CDKN1A expression via mRNA stability
  • is a novel player in the TP53 pathway, which may be explored to restore proper cell cycle control in TP53-deficient tumors via CDKN1A
  • is required for skeletal muscle differentiation
  • is a novel key regulator of the myogenic differentiation program during vertebrate development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • is a novel regulator of TP63 via mRNA stability
    • cell & other
    REGULATION
    induced by induced by DNA damage and MDM2 inhibitor Nutlin-3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    implicated in cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS