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FLASH GENE

Symbol

SEMA3B

contributors: mct/npt - updated : 16-11-2016

HGNC name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
HGNC id	10724

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.53 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001005914 18 - 2986 NP_001005914 - 748 - Koyama (2008) NM_004636 18 - 2989 NP_004627 - 749 - Koyama (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach         Endocrine adrenal gland       highly Nervous brain           nerve cranial nerve     highly Reproductive female system ovary         female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal peptide
	the SEMA domain containing about 14 cysteine residues
	an Ig-like motif
	a C terminal short basic domain

HOMOLOGY

Homologene

FAMILY

semaphorin family

CATEGORY

secretory , tumor suppressor

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	repellent of the nerve growth cone guidance
	inhibiting axonal extension by providing local signals to specify territories inaccessible for growing axons
	may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure (Lallier 2004)
	can act as a tumor suppressor by inducing apoptosis either by reexpression in tumor cells or applied as a soluble ligand (Castro-rivera 2004)
	angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases (Varshavsky 2008)
	role of the PLXNA2 receptor in SEMA3A and SEMA3B signal transduction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

member of class 3 semaphorins (Koyama 2008)

INTERACTION

DNA

RNA

small molecule

protein	interacting with VEGF(compete with SEMA3B for binding on the cell surface and antagonizing the negative regulatory effect of SEMA3B on cell growth)
	interacting with IGFBP6 (IGFBP6 is the effector of tumor suppressor activity of SEMA3B)(Koyama 2008)
	interacting with VEGFA (VEGFA, produced by tumor cells, acts as an autocrine survival factor and SEMA3B mediates its tumor-suppressing effects, at least in part, by blocking this VEGF autocrine activity)(Castro-Rivera 2004)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in breast and non-small cell lung cancer tumoral       loss of function by hypermethylation in non-small cell lung cancer tumoral     --low   by hypermethylation in hepatocellular carcinomas and cholangiocarcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS