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FLASH GENE

Symbol

SLAMF6

contributors: mct - updated : 16-02-2016

HGNC name	SLAM family member 6
HGNC id	21392

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q23.3      Physical location : 160.454.819 - 160.493.052
Synonym name	natural killer-, T- and B-cell antigen
Synonym symbol(s)	KALI, NTBA, KALIb, Ly108, SF2000, NTB-A, CD352

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	38.23 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001184716 7 - 2421 NP_001171645 - 221 - 2010 20146065 NM_001184715 8 - 2604 NP_001171644 - 282 - 2010 20146065 NM_052931 8 - 2751 NP_443163 - 331 - 2010 20146065 NM_001184714 8 - 2754 NP_001171643 - 332 - 2010 20146065

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus         Homo sapiens Fetal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Lymphoid/Immune natural killer Lymphoid/Immune T cell

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a peptide signal
	seven potential N-linked glycosylation sites in its 204-residue extracellular region
	a transmembrane region lacking charged residues
	an immunoreceptor tyrosine-based inhibitory motif (ITIM)
	SAP-binding motifs in short cytoplasmic tail

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY	CD2 subfamily of the immunoglobulin superfamily
	signaling lymphocyte activation molecule (SLAM) family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	type 1 transmembrane protein

basic FUNCTION	may be functioning as a coreceptor in the process of NK cell activation
	can enhance the lysis of target cells through the interaction with another SLAMF6 on the surface of NK cells
	involved in regulation of interferon-gamma secretion, inhibition of Th1 cell-induced isotype switching
	can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients
	SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
	plays an important role in T cell co-stimulation
	functions as a SH2D1A adaptor-dependent on-off switch for T cell help to B cells and NKT cell development
	natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
	central role for germinal center (GC) B cell-specific CD84 and SLAMF6 expression in maintaining B cell tolerance in GCs and in preventing autoimmunity
	SLAMF1, CD84, and SLAMF6 are important negative regulators of humoral immune response, consistent with the notion that SLAM family receptors have dual functions in immune responses

CELLULAR PROCESS	cell life, proliferation/growth
	cell communication

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

LY9/SLAMF6 signaling mediates increased nuclear abundance and recruitment of RORC to the proximal IL17A promoter, resulting in increased trans-activation and gene expression

a component

INTERACTION

DNA

RNA

small molecule

protein	homophilic interaction, being its own ligand
	binding SH2D1A, EAT2
	interacting with PTPN6 and upon phosphorylation with PTPN11
	potential role for SLAMF6 in the induction of ZBTB16
	both SLAMF6-associated LCK phosphorylation and kinase activity were enhanced in restimulated T cells, amplifying proximal TCR signaling
	SH2D1A facilitates recruitment and activation of LCK at SLAMF6 receptors during restimulation-induced cell death

cell & other

REGULATION

Other	up-regulated on activated T cells
	its tyrosine phosphorylation regulates the signal transduction
	is dynamically regulated in the thymus

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   LY9 and SLAMF6 expression is increased on the surface of SLE T cells compared with normal cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

deletion of Slamf6 in CD4(+) T cells reversed the Sh2D1a(-/-) phenotype, eliminating the SH2D1A requirement for germinal centers