motifs/domains
| N terminus containing a 15-AA sequence that mediates trafficking to the cilium, and a related N-terminal ciliary-targeting sequence similarly to PKD1, that binds ARF4  |
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six transmembrane spans, a pore forming region, and cytoplasmic N- and C-terminal tails |
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N and C terminal second dimerization domain leading to homotetrameric form (N-terminal dimerization domain is not critical for the function of ER PKD2 channels but is required for the function of surface PKD2 channels) |
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a PKHD1-binding domain in the intracellular N terminus |
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phosphorylation site within its N-terminal domain having significant role for the maintenance of normal glomerular and tubular morphology |
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six transmembrane segments (6TM) |
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a large extracellular loop between TM1 and 2 |
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five N-glycosylation sites |
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several phosphorylation sites |
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a transient receptor potential channel subunit motif (TRP), dimerizing with TRPC1 or PKD1 |
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a coiled-coil domain including an EF hand calcium binding domain in the C terminus critical for the formation of the complex PKD2/PKD1 , that functions as a homodimerization domain essential for PKD1 binding but not for its self-oligomerization |
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C terminus required for the interaction with the |
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AKAP5 complex |
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Cterm protein contains a Ca(2+)-binding site responsible for channel gating and function |
SUBCELLULAR LOCALIZATION
| plasma membrane,junction
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| text
| basolateral plasma membrane of kidney tubular epithelial cells |
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localized on the ER membrane as a Ca release channel |
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Type II membrane protein |
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ER localization plays an important role in the development of normal Left-Right asymmetry |
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localized at the endoplasmic reticulum (ER) membrane significantly enhanced Ca2+ release from the ER upon muscarinic acetylcholine receptor (mAChR) stimulation |
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besides its localization in the primary cilium, is present in the endoplasmic reticulum (ER), the PM, the adherens junctions and the basolateral cell surface of kidney epithelial cells |
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with PKD1, colocalize to cilia, where they may enable a mechano/chemosensory response triggering a rise in intracellular Ca2+ |
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located in the primary cilium where it is thought to transmit mechanical stimuli into the cell interior |
| basic FUNCTION
| Ca2+ permeable non selective cation channel with a high permeability to Ca2+ |
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modulating Ca2+ entry in response to G-protein coupled receptor activation and/or store depletion |
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mediating mechanosensation in the primary cilium of kidney cells |
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function as a nonselective cation channel in the plasma membrane |
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acting as a negative regulator of cell growth, and may also play an important role in the regulation of tubulogenesis |
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playing a necessary role for the proper growth and differentiation of kidney epithelial cells |
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traffics to cilia independently of polycystin-1 by using an N-terminal RVXP motif |
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showing a pattern of single-channel conductance, amiloride sensitivity and ion permeability distinct from that of PKD2 alone |
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TRP-type Ca(2+)-permeable non-selective cation channel, present and functional in microtubule-containing primary cilia of renal epithelial cells, and having a regulatory role in the sensory function of primary cilia |
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in the ER plays a role in cellular Ca2+ homeostasis |
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represses cell proliferation through promoting the phosphorylation of eukaryotic translation initiation factor eIF2A by pancreatic ER-resident eIF2 alpha kinase (EIF2AK3) |
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important regulator of the translation machinery |
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important for regulation of RyR2 function |
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calcium permeable nonselective cation channel implicated in the regulation of cardiac development, renal tubular differentiation, and left-to-right (L-R) axis determination |
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may be assuming distinct subcellular localizations to exert tissue-specific functions |
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protects cells from apoptosis by lowering the Ca2+ concentration in the endoplasmic reticulum (ER) |
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having an important function in the modulation of intracellular Ca2+ signalling |
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modulating the cleavage of PKD1 |
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functions as a Ca2+-permeable nonselective cation channel, ER-localized, interacting with the ER Ca2+ channel, inositol 1,4,5-trisphosphate receptor (ITPR1), to promote ER Ca2+ release |
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inhibits stretch-activated ions channels |
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acting as a Ca2+ release channel of intracellular stores and functionally interact with inositol 1,4,5-trisphosphate receptor-induced Ca2+ release |
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also acts as an intracellular Ca2+-release channel in the endoplasmic reticulum (ER) where it interacts with the inositol-1,4,5 trisphosphate (InsP3) receptor and ryanodine receptor |
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RP2 and PKD2 function in a common developmental process ( |
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its expression is required for the movement of PKD1 to the plasma and ciliary membranes |
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functions as a non-selective cation channel in the endoplasmic reticulum and possibly at the plasma membrane |
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mediates sensory perception on cilia and flagella |
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PKD1L1 and PKD2 form a complex that functions as the nodal flow sensor in the motile cilia of the medaka Kupffer's vesicle |
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PKD2 modulates intracellular calcium cycling, contributing to the development of heart failure |
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PKD2 contributes to Ca2+ transport and cell signaling in renal epithelia and other tissues |
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PKD1, PKD2 form an ion channel complex that may mediate ciliary sensory processes and regulate endoplasmic reticulum (ER) Ca2+ release |
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role for PKD1, PKD2 in sensing and responding to cellular O2 levels |
