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FLASH GENE
Symbol UNC5CL contributors: - updated : 16-09-2004
HGNC name unc-5 homolog C (C. elegans)-like
HGNC id 21203
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ZU5 domain
  • a DEATH domain
    • HOMOLOGY
    interspecies homolog to murine Unc5cl
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in inhibition of NF-kappaB activation by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB mediated transcription)
  • sensitizes cells to apopotosis induced by TNF and TRAIL
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with NF-kappaB subunit p105 and transactivator p65
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS