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FLASH GENE
Symbol UNC5CL contributors: - updated : 16-09-2004
HGNC name unc-5 homolog C (C. elegans)-like
HGNC id 21203
Location 6p21.1      Physical location : 40.994.639 - 41.006.938
Synonym name ZU5 and death domain-containing protein
Synonym symbol(s) MGC34763, ZUD
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ZU5 domain
  • a DEATH domain
    • HOMOLOGY
    interspecies homolog to murine Unc5cl
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in inhibition of NF-kappaB activation by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB mediated transcription)
  • sensitizes cells to apopotosis induced by TNF and TRAIL
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with NF-kappaB subunit p105 and transactivator p65
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS