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FLASH GENE
Symbol RAP2C contributors: mct - updated : 16-12-2014
HGNC name RAP2C, member of RAS oncogene family
HGNC id 21165
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RAS domain
  • a CAAX motif at the C-terminus
    • conjugated LipoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Rap2c
    homolog to rattus LOC302495
    Homologene
    FAMILY
  • small GTPase superfamily
  • Ras family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • localizing and recruiting TNIK to the recycling endosomes in a palmitoylation dependent manner (Uechi, 2009)
    • basic FUNCTION
  • signal transduction activity
  • may be involved in serum response element-mediated gene transcription
  • contribute to the still poorly clarified cellular events regulated by this subfamily of GTP-binding proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • bind guanine nucleotides with peculiar properties
  • F11R associates directly with TJP2 and indirectly with afadin, and this complex, along with RAPGEF2, activates the small GTPase RAP2C
  • is spatially segregated from RAP2A signaling as it is not enriched at the apical membrane after polarization
    • cell & other
    REGULATION
    repressed by during platelets generation
    Other requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi, 2009)
    requires palmitoylation for membrane association and TNIK activation (Uechi, 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS