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FLASH GENE

Symbol

RAP2C

contributors: mct - updated : 16-12-2014

HGNC name	RAP2C, member of RAS oncogene family
HGNC id	21165

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq26.2      Physical location : 131.337.053 - 131.352.189
Synonym symbol(s)	DKFZp313B211

DNA

TYPE	functioning gene
STRUCTURE	16.46 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021183 4 - 3933 NP_067006 - 183 - 2007 17447155 NM_001271187 6 - 3341 NP_001258116 - 117 - 2007 17447155 NM_001271186 6 - 4006 NP_001258115 - 183 - 2007 17447155

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine rectum   highly   liver       highly   stomach       predominantly Reproductive female system uterus     highly   male system prostate     predominantly Urinary bladder       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   predominantly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic megakaryocyte Blood/Hematopoietic platelet

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RAS domain
	a CAAX motif at the C-terminus

conjugated

LipoP

mono polymer

monomer

HOMOLOGY

interspecies	homolog to murine Rap2c
	homolog to rattus LOC302495

Homologene

FAMILY	small GTPase superfamily
	Ras family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic
text	localizing and recruiting TNIK to the recycling endosomes in a palmitoylation dependent manner (Uechi, 2009)

basic FUNCTION	signal transduction activity
	may be involved in serum response element-mediated gene transcription
	contribute to the still poorly clarified cellular events regulated by this subfamily of GTP-binding proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	bind guanine nucleotides with peculiar properties
	F11R associates directly with TJP2 and indirectly with afadin, and this complex, along with RAPGEF2, activates the small GTPase RAP2C
	is spatially segregated from RAP2A signaling as it is not enriched at the apical membrane after polarization

cell & other

REGULATION

repressed by

during platelets generation

Other	requires palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading (Uechi, 2009)
	requires palmitoylation for membrane association and TNIK activation (Uechi, 2009)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS