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FLASH GENE
Symbol FAM120B contributors: npt/mct - updated : 15-01-2021
HGNC name family with sequence similarity 120B
HGNC id 21109
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four LXXLL motifs, which are characteristic for nuclear receptor coactivators (Li 2007)
    • HOMOLOGY
    interspecies ortholog to murine 4932442K08Rik
    Homologene
    FAMILY
  • constitutive coactivator of PPAR-gamma family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized in nucleus (Li 2007)
    basic FUNCTION
  • coactivator that promotes adipogenesis in a PPARgamma-dependent manner (Li 2007)
  • is a 5' exonuclease that acts independently of the Fanconi anemia (FA) pathway in response to interstrand DNA cross-links (ICLs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the hinge region of PPARgamma in a ligand-independent manner (Li 2007)
  • FAM120B binds to Senataxin (SETX), an RNA/DNA helicase that resolves R-loops
  • functions with SETX in a pathway necessary for resistance to interstrand DNA cross-links (ICLs)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS