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FLASH GENE
Symbol FAM120B contributors: npt/mct - updated : 15-01-2021
HGNC name family with sequence similarity 120B
HGNC id 21109
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine   
Endocrineneuroendocrinepituitary   
Lymphoid/Immunespleen   highly
Nervousbrain    
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four LXXLL motifs, which are characteristic for nuclear receptor coactivators (Li 2007)
    • HOMOLOGY
    interspecies ortholog to murine 4932442K08Rik
    Homologene
    FAMILY
  • constitutive coactivator of PPAR-gamma family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized in nucleus (Li 2007)
    basic FUNCTION
  • coactivator that promotes adipogenesis in a PPARgamma-dependent manner (Li 2007)
  • is a 5' exonuclease that acts independently of the Fanconi anemia (FA) pathway in response to interstrand DNA cross-links (ICLs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the hinge region of PPARgamma in a ligand-independent manner (Li 2007)
  • FAM120B binds to Senataxin (SETX), an RNA/DNA helicase that resolves R-loops
  • functions with SETX in a pathway necessary for resistance to interstrand DNA cross-links (ICLs)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS