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FLASH GENE

Symbol

FAM120B

contributors: npt/mct - updated : 15-01-2021

HGNC name	family with sequence similarity 120B
HGNC id	21109

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	117.05 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032448 11 - 3261 NP_115824 - 910 - 2018 29968717 NM_001286379 11 - 5440 NP_001273308 - 922 - 2018 29968717 NM_001286380 11 - 5203 NP_001273309 - 933 - 2018 29968717 NM_001286381 8 - 3219 NP_001273310 - 242 - 2018 29968717

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine small intestine       Endocrine neuroendocrine pituitary       Lymphoid/Immune spleen       highly Nervous brain         Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four LXXLL motifs, which are characteristic for nuclear receptor coactivators (Li 2007)

HOMOLOGY

interspecies

ortholog to murine 4932442K08Rik

Homologene

FAMILY

constitutive coactivator of PPAR-gamma family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	localized in nucleus (Li 2007)

basic FUNCTION	coactivator that promotes adipogenesis in a PPARgamma-dependent manner (Li 2007)
	is a 5' exonuclease that acts independently of the Fanconi anemia (FA) pathway in response to interstrand DNA cross-links (ICLs)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with the hinge region of PPARgamma in a ligand-independent manner (Li 2007)
	FAM120B binds to Senataxin (SETX), an RNA/DNA helicase that resolves R-loops
	functions with SETX in a pathway necessary for resistance to interstrand DNA cross-links (ICLs)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS